Ginger and Nausea
Hands down, ginger’s most well researched and popular medicinal use is for nausea. Ginger is believed to help alleviate nausea by increasing the tone, motility, and emptying rate of the stomach. Ginger has been shown to have beneficial effects on nausea during pregnancy, chemotherapy-induced nausea, motion sickness, and post-surgery nausea. For pregnancy related nausea, one systematic review of the research suggested that up to 1,500 mg a day in divided doses appear to be most beneficial.2 For most other causes of nausea, ginger is probably best taken as a prophylactic. Doses ranging from 500 to 2,000 mg divided per day have been used with the onset of use starting as early as 5 days before chemotherapy treatment and continuing for several days after, and up to one hour prior to surgery or travel and continuing on every 1-4 hours for motion sickness.3
Ginger and Digestion
In addition to relieving nausea, ginger also shines as a general digestive tonic. Health Canada’s ginger monograph lists relief of digestive upsets, lack of appetite, digestive spasms, and indigestion among ginger’s benefits. Ginger also appears to have a positive effect on gut microbiota, acting as a prebiotic, improving microbial community richness, and lowering the pH of the colon, which promotes the proliferation of beneficial bacteria.4 5 These microbiome benefits may reach beyond the digestive tract and may contribute to many of ginger’s anti-inflammatory effects.
Ginger and Pain
Ginger has been shown to have anti-inflammatory and analgesic properties, leading researchers to explore the ways it may improve pain conditions. Several studies have examined its effect on menstrual cramps (aka dysmenorrhea) and have found that ginger is effective for reducing pain and nausea and is as effective as NSAIDs.6 7 8 Other lines of research have investigated ginger for osteoarthritic pain and found doses of 500 to 1,000 mg a day for three to twelve weeks to be safe and effective.9 10 11 In a few small studies, ginger taken up to 2 weeks prior to prolonged running or eccentric exercise (when the muscle lengthens, e.g. when you straighten your arm to lower the weight down in a dumbbell curl) reduced pain and improved post-exercise recovery.12 13 14 And finally, migraine sufferers may also benefit from ginger’s pain- and nausea-reducing effects.15 16
Ginger and Blood Sugar
Blood sugar balance is a critical piece of overall health and finding ways to support it are of the utmost importance. While blood sugar balance starts with how you eat, ginger may be one way to add some additional support. Numerous studies have found ginger to improve markers of blood sugar regulation such as hemoglobin A1C (HbA1C)—a test that provides a snapshot of your average glucose levels over the past 6 weeks—and fasting glucose, and to improve oxidative stress markers and reduce inflammation.17 18 19 20 21 22 23
Ginger’s Other Possible Benefits
Through its mechanisms of action, ginger could potentially have a positive effect on numerous other aspects of human health. For instance, very preliminary research suggests ginger may inhibit proliferation and growth of cancer tumors.24 25 26 Some of ginger’s bioactive compounds appear to be capable of crossing the blood-brain-barrier, prompting some to suggest ginger may be protective against neurodegenerative diseases such as Parkinson’s disease and Multiple Sclerosis.27 28 29 30 In animal studies, ginger appears to support healthy testosterone levels and male fertility.31 32 33 34 While more research is needed to confirm these possible benefits, ginger may be a valuable addition whenever extra antioxidant or anti-inflammatory support is needed.
Using Ginger Supplements
While you could certainly eat fresh ginger every day or drink ginger tea, nearly all the research has used ginger supplements in a powdered or extracted form, which may give supplements an edge therapeutically and certainly convenience-wise. Both as food and as supplements ginger is exceedingly safe, with the most common adverse events being mild heartburn, indigestion, and nausea, and usually only with higher doses. Most studies have used 1,000 to 4,000 mg a day in divided doses.35
Ginger Essential Oil
The power of ginger can also be harnessed for topical use through ginger essential oil (EO). Ginger EO has many of the same properties as fresh or extracted ginger, such as anti-inflammatory, analgesic, and digestive tonic. Ginger EO is best added to lotion or a carrier oil to avoid skin irritation and can be used to massage achy joints, rubbed over the belly for digestive complaints (always in a clockwise direction, lower right side to upper right side to upper left side, etc.), to warm cold hands and feet, or over the chest for respiratory ailments. Ginger EO can be inhaled or used in a diffuser to sharpen the senses, aid in memory, and decrease brain and nervous exhaustion and it has a reputation as an aphrodisiac. Ginger EO should not be used during pregnancy or on babies.36
References
- Bode, A.M., Dong, Z. (2011). The amazing and might ginger. In Benzie, I.F.F., Wachetl-Galor, S. (eds). Herbal Medicine: biomolecular and Clinical Aspects, 2nd ed. CRC Press/Taylor & Francis. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92775/
- Viljoen, E., Visser, J., Koen, N., Musekiwa, A. (2014). A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J, 13, 20. doi: 10.1186/1475-2891-13-20
- Nikkhah Bodagh, M., Maleki, I., & Hekmatdoost, A. (2018). Ginger in gastrointestinal disorders: A systematic review of clinical trials. Food science & nutrition, 7(1), 96–108. https://doi.org/10.1002/fsn3.807
- Wang, J., Chen, Y., Hu, X., Feng, F., Cai, L., & Chen, F. (2020). Assessing the Effects of Ginger Extract on Polyphenol Profiles and the Subsequent Impact on the Fecal Microbiota by Simulating Digestion and Fermentation In Vitro. Nutrients, 12(10), 3194. https://doi.org/10.3390/nu12103194
- Wang, X., Zhang, D., Jiang, H., Zhang, S., Pang, X., Gao, S., Zhang, H., Zhang, S., Xiao, Q., Liyuan, C., Wang, S., Qi, D., Li, Y. (2021). Gut microbiota variation with short-term intake of ginger juice on human health. Front Microbiol, 11: 576061. DOI: https://doi.org/10.3389/fmicb.2020.576061
- Negi, R., Sharma, S. K., Gaur, R., Bahadur, A., & Jelly, P. (2021). Efficacy of Ginger in the Treatment of Primary Dysmenorrhea: A Systematic Review and Meta-analysis. Cureus, 13(3), e13743. https://doi.org/10.7759/cureus.13743
- Adib Rad, H., Basirat, Z., Bakouei, F., Moghadamnia, A. A., Khafri, S., Farhadi Kotenaei, Z., Nikpour, M., & Kazemi, S. (2018). Effect of Ginger and Novafen on menstrual pain: A cross-over trial. Taiwanese journal of obstetrics & gynecology, 57(6), 806–809. https://doi.org/10.1016/j.tjog.2018.10.006
- Rondanelli, M., Fossari, F., Vecchio, V., Gasparri, C., Peroni, G., Spadaccini, D., Riva, A., Petrangolini, G., Iannello, G., Nichetti, M., Infantino, V., & Perna, S. (2020). Clinical trials on pain lowering effect of ginger: A narrative review. Phytotherapy research : PTR, 34(11), 2843–2856. https://doi.org/10.1002/ptr.6730
- Bartels, E. M., Folmer, V. N., Bliddal, H., Altman, R. D., Juhl, C., Tarp, S., Zhang, W., & Christensen, R. (2015). Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis and cartilage, 23(1), 13–21.
https://doi.org/10.1016/j.joca.2014.09.024
- Wigler, I., Grotto, I., Caspi, D., & Yaron, M. (2003). The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis and cartilage, 11(11), 783–789. https://doi.org/10.1016/s1063-4584(03)00169-9
- Araya-Quintanilla, F., Gutierrez-Espinoza, H., Munoz-Yanez, M. J., Sanchez-Montoya, U., & Lopez-Jeldes, J. (2020). Effectiveness of Ginger on Pain and Function in Knee Osteoarthritis: A PRISMA Systematic Review and Meta-Analysis. Pain physician, 23(2), E151–E161.
- Black, C.D., Herring, M.P., Hurley, D.J., O’Connor, P.J. (2010). Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain, 11(9), 894-903. DOI: 10.1016/j.jpain.2009.12.013
- Wilson P. B. (2015). Ginger (Zingiber officinale) as an Analgesic and Ergogenic Aid in Sport: A Systemic Review. Journal of strength and conditioning research, 29(10), 2980–2995. https://doi.org/10.1519/JSC.0000000000001098
- [14] Matsumura, M. D., Zavorsky, G. S., & Smoliga, J. M. (2015). The Effects of Pre-Exercise Ginger Supplementation on Muscle Damage and Delayed Onset Muscle Soreness. Phytotherapy research : PTR, 29(6), 887–893. https://doi.org/10.1002/ptr.5328
- Andrade C. (2021). Ginger for Migraine. The Journal of clinical psychiatry, 82(6), 21f14325. https://doi.org/10.4088/JCP.21f14325
- Chen, L., & Cai, Z. (2021). The efficacy of ginger for the treatment of migraine: A meta-analysis of randomized controlled studies. The American journal of emergency medicine, 46, 567–571. https://doi.org/10.1016/j.ajem.2020.11.030
- Carvalho, G., Lira-Neto, J., Araújo, M., Freitas, R., Zanetti, M. L., & Damasceno, M. (2020). Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial. Revista latino-americana de enfermagem, 28, e3369. https://doi.org/10.1590/1518-8345.3870.3369
- Arablou, T., Aryaeian, N., Valizadeh, M., Sharifi, F., Hosseini, A., & Djalali, M. (2014). The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. International journal of food sciences and nutrition, 65(4), 515–520. https://doi.org/10.3109/09637486.2014.880671
- Shidfar, F., Rajab, A., Rahideh, T., Khandouzi, N., Hosseini, S., & Shidfar, S. (2015). The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Journal of complementary & integrative medicine, 12(2), 165–170. https://doi.org/10.1515/jcim-2014-0021
- Makhdoomi Arzati, M., Mohammadzadeh Honarvar, N., Saedisomeolia, A., Anvari, S., Effatpanah, M., Makhdoomi Arzati, R., Yekaninejad, M. S., Hashemi, R., & Djalali, M. (2017). The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, and Lipid Profiles in Patients with Type 2 Diabetes. International journal of endocrinology and metabolism, 15(4), e57927. https://doi.org/10.5812/ijem.57927
- Shidfar, F., Rajab, A., Rahideh, T., Khandouzi, N., Hosseini, S., & Shidfar, S. (2015). The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Journal of complementary & integrative medicine, 12(2), 165–170. https://doi.org/10.1515/jcim-2014-0021
- Makhdoomi Arzati, M., Mohammadzadeh Honarvar, N., Saedisomeolia, A., Anvari, S., Effatpanah, M., Makhdoomi Arzati, R., Yekaninejad, M. S., Hashemi, R., & Djalali, M. (2017). The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, and Lipid Profiles in Patients with Type 2 Diabetes. International journal of endocrinology and metabolism, 15(4), e57927. https://doi.org/10.5812/ijem.57927
- Arablou, T., Aryaeian, N., Valizadeh, M., Sharifi, F., Hosseini, A., & Djalali, M. (2014). The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. International journal of food sciences and nutrition, 65(4), 515–520. https://doi.org/10.3109/09637486.2014.880671
- de Lima, R., Dos Reis, A. C., de Menezes, A., Santos, J., Filho, J., Ferreira, J., de Alencar, M., da Mata, A., Khan, I. N., Islam, A., Uddin, S. J., Ali, E. S., Islam, M. T., Tripathi, S., Mishra, S. K., Mubarak, M. S., & Melo-Cavalcante, A. (2018). Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review. Phytotherapy research : PTR, 32(10), 1885–1907. https://doi.org/10.1002/ptr.6134
- Li, Y., Li, S., Meng, X., Gan, R.Y., Zhang, J.J., Li, H.B. (2017). Dietary natural products for the prevention and treatment of breast cancer. Nutrients, 9(7), 728. doi: 10.3390/nu9070728
- Zadorozhna, M., Mangieri, D. (2021). Mechanisms of chemopreventive and therapeutic properties of ginger extracts in cancer. Int J Mol Sci, 22(1), 6599. doi: 10.3390/ijms22126599
- Simon, A., Darcsi, A., Kéry, A., Riethmüller, E. (2020). Blood-brain barrier permeability study of ginger constituents. J Pharm Biomed Anal, 177, 112820. DOI: 10.1016/j.jpba.2019.112820
- Arcusa, R., Villaño, D., Marhuenda, J., Cano, M., Cerdà, B., & Zafrilla, P. (2022). Potential Role of Ginger (Zingiber officinale Roscoe) in the Prevention of Neurodegenerative Diseases. Frontiers in nutrition, 9, 809621. https://doi.org/10.3389/fnut.2022.809621
- Park, G., Kim, H. G., Ju, M. S., Ha, S. K., Park, Y., Kim, S. Y., & Oh, M. S. (2013). 6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation. Acta pharmacologica Sinica, 34(9), 1131–1139. https://doi.org/10.1038/aps.2013.57
- Jafarzadeh, A., & Nemati, M. (2018). Therapeutic potentials of ginger for treatment of Multiple sclerosis: A review with emphasis on its immunomodulatory, anti-inflammatory and anti-oxidative properties. Journal of neuroimmunology, 324, 54–75. https://doi.org/10.1016/j.jneuroim.2018.09.003
- Banihani S. A. (2018). Ginger and Testosterone. Biomolecules, 8(4), 119. https://doi.org/10.3390/biom8040119
- Morakinyo, A.O., Adeniyi, O.S., Arikawe, A.P. (2008). Effects of Zingiber officinale on reproductive functions in the male rat. African J Biomed Res, 11(3), 329-334. Retrieved from https://www.ajol.info/index.php/ajbr/article/view/50750
- Gholami-Ahangaran, M., Karimi-Dehkordi, M., Akbari Javar, A., Haj Salehi, M., & Ostadpoor, M. (2021). A systematic review on the effect of Ginger (Zingiber officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans. Veterinary medicine and science, 7(5), 1959–1969. https://doi.org/10.1002/vms3.538
- Banihani S. A. (2019). Effect of ginger (Zingiber officinale) on semen quality. Andrologia, 51(6), e13296. https://doi.org/10.1111/and.13296
- n.a. (2003). Monograph: Zingiber officinale (Ginger). Alt Med Rev, 8(3), 331-335. Retrieved from https://altmedrev.com/wp-content/uploads/2019/02/v8-3-331.pdf
- Glenn, L. (ed). (2017, July 14). Ginger Essential Oil. HerbClip. Retrieved from: https://www.herbalgram.org/resources/herbclip/herbclip-news/2017/ginger-essential-oil/